Voltage Clamp of Cardiac Muscle in a Double Sucrose Gap
نویسندگان
چکیده
منابع مشابه
Limitations of the double sucrose gap voltage clamp technique in tension-voltage determinations on frog atrial muscle.
The purpose of this study was to evaluate the limitations of the double sucrose gap voltage clamp technique in the determination of tension-voltage relationships for frog atrial muscle. Tension-voltage relationships were determined under two conditions. In one case we determined both the tension response and slow inward current associated with an apparent step depolarization (step-clamp) as a f...
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Voltage clamp responses of a single excitable fiber were simulated using a core conductor model including a high external resistance (Rs) in series to the fiber membrane to allow for intercellular clefts in a multifiber preparation. In terms of specific resistance, Rs was between 68 and 264 omega cm2. Internal resistivity (Ri) was taken to be zero or 200 omega cm. The aim of the study was to qu...
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1. Membrane currents during step depolarizations were determined by a method in which three electrodes were inserted near the end of a fibre in the frog's sartorius muscle. The theoretical basis and limitations of the method are discussed.2. Measurements of the membrane capacity (C(M)) and resting resistance (R(M)) derived from the current during a step change in membrane potential are consiste...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1973
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(73)86013-8